Mirtazapine was prepared by a seven-step reaction, namely nucleophilic ring-opening reaction, chlorination, cyclization,摘要以环氧苯乙烯和N-甲基乙醇胺为起始原料，经亲核开环、氯代和环合反应得到中间体1-甲基－3-苯基哌嗪。
Comparing Study of Mirtazapine and Amitriptyline on Treating Depression with Chronic Pain;米氮平与阿米替林治疗抑郁症并发慢性疼痛的对照研究