Mirtazapine was prepared by a seven-step reaction, namely nucleophilic ring-opening reaction, chlorination, cyclization, uncleophilic substitution, hydrolysis, reduction and cyclization from styrene oxide and N-methylethanolamine as the starting materials
Mirtazapine was prepared by a seven-step reaction, namely nucleophilic ring-opening reaction, chlorination, cyclization, uncleophilic substitution, hydrolysis, reduction and cyclization from styrene oxide and N-methylethanolamine as the starting materials
摘要以环氧苯乙烯和N-甲基乙醇胺为起始原料，经亲核开环、氯代和环合反应得到中间体1-甲基－3-苯基哌嗪。