Research on E.coli protease system is the basis of engineering strain improvement In order to reduce their negative effe为减少蛋白酶对外源蛋白的降解，从不同的角度做了大量工作，其中利用反义RNA技术控制蛋白酶活性是一条值得探索的思路。
Study on the Strain Improvement by Protoplast Fusion and Its Molecular Biology from Micromonospora Inyoensis依尼奥小单孢菌原生质体融合育种及其分子生物学研究