Long-term clinical findings showed that latanoprost induced the manifestations of diffuse lash hypertrophy and hyperpigm长期临床观察发现，开角型青光眼和眼压增高的患者局部应用拉坦前列素治疗时，绝大多数患者会出现睫毛增长、增粗、色泽加深、上下眼睑周围出现多毛表现、皮肤色素沉着。