Inbreeding increases homozygosity so that deleterious recessive genes are expressed more often in the phenotype, and dec近亲交配使纯合体几率增加，因此，一些有害的隐性基因可以被表达。
LOH at q existed in all tenascin positive crypts implying genetic homozygosity,while LOH at 8q showed genetic heterozygoq位点的LOH在所有TN阳性染色腺体中呈遗传均一性 ,而8q位点LOH表现为遗传不均一性。