The histopathological changes were evaluated through light microscope after disarticulation sections (H.E. stain), and t黏多醣类分布的变化则将切片经硷性蓝染色后以欧帝玛扫瞄仪加以分析，并将其对严重度指标的改变及组织病理学上的变化上的相关性作进一步探讨。