2. Exogenous ceramide can in certain extent increase the cell's free Ca2+ as well as induce the NIH 3T3 cell apoptosis, increased was mainly come from the extracellular cadium initiated by cadium exhausting.
2. Exogenous ceramide can in certain extent increase the cell's free Ca2+ as well as induce the NIH 3T3 cell apoptosis, increased was mainly come from the extracellular cadium initiated by cadium exhausting.
2.外源性神经酰胺在一定的剂量范围内可以导致NIH3T3细胞的凋亡和细胞内游离钙的升高并且有一定的剂量依赖性关系,这说明Ca~(2+)参与了凋亡信号的传递; 胞内游离钙的增加主要来源于钙池耗竭引发的外Ca~(2+)内流;