Objective Shigellosis was investigated among outpatients with diarrhea in Wuhan, serotype distribution and drug resistance of Shigellae was analyzed, the mechanism of fluroquinolones-resistant was studied and a genotyping method for Shigella spp.
Objective Shigellosis was investigated among outpatients with diarrhea in Wuhan, serotype distribution and drug resistance of Shigellae was analyzed, the mechanism of fluroquinolones-resistant was studied and a genotyping method for Shigella spp.
目的和意义 通过调查武汉市2004年流行季节门诊腹泻患者志贺菌感染状况,分析志贺菌血清型分布及耐药现状,并与2003年做相关比较,研究志贺菌中氟喹诺酮作用靶位点的改变导致氟喹诺酮耐药的机制,并用分子生物学方法对志贺菌进行基因分型,为志贺菌耐药性监测、临床合理用药、新药和疫苗开发及流行病学研究提供理论依据。