Objective To observe the changes of blood fentanyl concentration in rats during anhepatic phase by treatment of large dose of dexamethasone and to investigate the extrahepatic metabolism of fentanyl.
Objective To observe the changes of blood fentanyl concentration in rats during anhepatic phase by treatment of large dose of dexamethasone and to investigate the extrahepatic metabolism of fentanyl.
目的揭示大剂量地塞米松处理后大鼠无肝期血药浓度变化规律,探讨芬太尼的肝外代谢及地塞米松对其肝外代谢的影响。