To investigate the effect of angiotensin converting enzyme antisense cDNA on the proliferation of vascular smooth muscle cells from SHR and WKY rats, and the machanism of antisense cDNA.
To investigate the effect of angiotensin converting enzyme antisense cDNA on the proliferation of vascular smooth muscle cells from SHR and WKY rats, and the machanism of antisense cDNA.
目的：研究脂质体介导的血管紧张素转化酶反义cDNA转染大鼠血管平滑肌细胞(VSMCs)和心脏成纤维细胞(Fbs)后的表达情况，以及转染对血管平滑肌细胞增殖和对心脏成纤维细胞合成胶原的的影响，在细胞水平探讨ACE反义cDNA治疗血管增殖性疾病和逆转心血管重构的可行性。