Conclusions: Cytokines (TNF-α, IL-1β, IFN-γ) enhance TLR4, MD-2 expression and promote the reaction with LPS, leading to overactivity of IEC with commensal bacteria, and accordingly initiate or perpetuate the intestinal inflammation.
Conclusions: Cytokines (TNF-α, IL-1β, IFN-γ) enhance TLR4, MD-2 expression and promote the reaction with LPS, leading to overactivity of IEC with commensal bacteria, and accordingly initiate or perpetuate the intestinal inflammation.
结论:细胞因子(TNF-α,IL-1β,IFN-γ)可增加肠上皮细胞TLR4和MD-2的表达,促进其对LPS的反应,引起肠上皮细胞对常驻菌的过度反应,从而启动或加重肠道炎症。