OBJECTIVE To establish a HPLC method for simultaneous determining rat plasma concentrations of 4″-O-glucosylvitexin (GLV) and 2″-O-rhamnosylvitexin (RHV) from Hawthorn Leaves Flavonoids (HLF) and study their pharmacokinetics in rats.
OBJECTIVE To establish a HPLC method for simultaneous determining rat plasma concentrations of 4″-O-glucosylvitexin (GLV) and 2″-O-rhamnosylvitexin (RHV) from Hawthorn Leaves Flavonoids (HLF) and study their pharmacokinetics in rats.
目的建立HPLC同时测定大鼠血浆中山楂叶总黄酮(HLF)的两个主要有效成分4″-O-牡荆素葡萄糖苷(GLV)和2″-O-牡荆素鼠李糖苷(RHV)的浓度,并用此方法对HLF在大鼠体内的药动学进行研究。