It was found that injection of okadaic acid into the Meynert nucleus basalis of rat brain induced hyperphosphorylation of tau at Ser-98/Ser-99/Ser-0 and Ser- 9/Ser-0 epitope, and decreased acetylcholine level accompanied with special memory deficit.
It was found that injection of okadaic acid into the Meynert nucleus basalis of rat brain induced hyperphosphorylation of tau at Ser-98/Ser-99/Ser-0 and Ser- 9/Ser-0 epitope, and decreased acetylcholine level accompanied with special memory deficit.
果发现 ,Meynert基底核注射OA后 ,Ach水平降低 ,τ蛋白在Ser 98/Ser 99/Ser 0 ,Ser 9 /Ser 0 位点发生过度磷酸化 ,并伴有大鼠空间记忆障碍 .