2. The concentration–time data of after oral administration in healthy volunteers were best fitted to two-compartment model. The main pharmacokinetics parameters were as follow: Cmax were (947.16±174.98)、(758.86±193.53) and (938.71±202.37) μg·L-1;
2. The concentration–time data of after oral administration in healthy volunteers were best fitted to two-compartment model. The main pharmacokinetics parameters were as follow: Cmax were (947.16±174.98)、(758.86±193.53) and (938.71±202.37) μg·L-1;
(2)健康志愿者口服环孢素A胶囊后,血药浓度时间-曲线符合二室模型,测得参比制剂新山地明胶囊及两种参比制剂因普兰他胶囊和田可胶囊药动学参数:Cmax分别为(947.16±174.98)、(758.86±193.53)和(938.71±202.37)μg·L-1;