In addition to strong IFN-γ inducing activity, IL-18 is able to induce production of Th1 cytokines such as GM-CSF, IL-2 and TNF-α to promote proliferation, development and differentiation of Th1 and activation of NK.
In addition to strong IFN-γ inducing activity, IL-18 is able to induce production of Th1 cytokines such as GM-CSF, IL-2 and TNF-α to promote proliferation, development and differentiation of Th1 and activation of NK.
除诱导细胞产生IFN-γ外，IL-18还能诱导GM-CSF，IL-2及TNF-α等其他Th1型细胞因子的产生，具有促进Th1细胞发育、增殖和分化以及增强NK细胞活性产生抗肿瘤作用。