Excess activation of Th2 cells evokes Th2 immune response, and it causes elevated Th2 cytokines. Th2 cytokines such as IL-4, IL-5 and IL-13 play a pivotal role on the onset and maintenance of airway allergic inflammation in asthma.
Excess activation of Th2 cells evokes Th2 immune response, and it causes elevated Th2 cytokines. Th2 cytokines such as IL-4, IL-5 and IL-13 play a pivotal role on the onset and maintenance of airway allergic inflammation in asthma.
“Th1/Th2偏移”假说被认为是哮喘发病的主要免疫学机制,该假说认为Th2细胞的过度活化导致了Th2反应为主的免疫反应,Th2型细胞因子IL-4、IL-5、IL-13等分泌增多在哮喘的气道炎症发生发展中起关键作用[3-5]。