and upregulate FasL expression on the cell surface of NK92.Conclusion:Preactivation of TM-TNF-α reverse signaling may potentiate NK-mediated cytotoxicity by promoting exocytosis, secretion of sTNF-α and FasL expression.
and upregulate FasL expression on the cell surface of NK92.Conclusion:Preactivation of TM-TNF-α reverse signaling may potentiate NK-mediated cytotoxicity by promoting exocytosis, secretion of sTNF-α and FasL expression.
结论TM-TNF-α反向信号可能通过促进NK92细胞胞吐、sTNF-α分泌及FasL的表达而促进NK92细胞对靶细胞的杀伤。