It acts as a catalytic subunit which interacts with the Fanconi animia core complex to induce the mono-ubiquitinylation of FANCD. The mono-ubiquitinylated FANCD, BCRCA and BCRCA constitute a complex which is concerned with the DNA repair.
It acts as a catalytic subunit which interacts with the Fanconi animia core complex to induce the mono-ubiquitinylation of FANCD. The mono-ubiquitinylated FANCD, BCRCA and BCRCA constitute a complex which is concerned with the DNA repair.
另一个则与人的范康尼氏贫血症(Fanconi animia)的发病有关,它作为一个催化亚基与范康尼氏贫血症核心复合物(Fanconi animia core complex)一起使得FANCD单素化,单泛素化后的FANCD将与BCRCA、BCRCA形成复合物参与DNA的修复过程[][]。