The structure of mirtazpine was confirmed by 1H-NMR (H^1-nuclear magnetic resonance) and MS (mass spectrum), and the purity was 99.79% by HPLC.
The structure of mirtazpine was confirmed by 1H-NMR (H^1-nuclear magnetic resonance) and MS (mass spectrum), and the purity was 99.79% by HPLC.
1-甲基－3-苯基哌嗪与2-氯－3-制氰基吡啶亲核取代，再经水解、还原和环合等反应得到米氮平，总收率为22.6%，结构经1H-NMR和MS（质谱）确认，HPLC含量为99.79%。