Biological activity of these analogs shows that Arg~B_(22) can be replaced by Lys or Asp. The results indicate that Arg~B_(22) is not essential for insulin aotivity. However, when Arg~B_(22) was substituted by D-Arg or Gly, their activities were very low.
Biological activity of these analogs shows that Arg~B_(22) can be replaced by Lys or Asp. The results indicate that Arg~B_(22) is not essential for insulin aotivity. However, when Arg~B_(22) was substituted by D-Arg or Gly, their activities were very low.
这些类似物的生物活性表明:Arg~(B_(22)能为Lys或Asp代替,这结果说明Arg~(B_(22))不是胰岛素活力所必需。但Arg~(B_(22))若为D-Arg或Giy代替,活力很低。