And to establish a novel complex rat model ofAlzheimer's disease(AD) which was induced by injection of basalnucleus of Meynert (BNM) with ibotenic acid(IBO) and 25-35β-amyloid peptide(Aβ_(25-35)).
And to establish a novel complex rat model ofAlzheimer's disease(AD) which was induced by injection of basalnucleus of Meynert (BNM) with ibotenic acid(IBO) and 25-35β-amyloid peptide(Aβ_(25-35)).
目的 从肾虚痰阻理论探讨老年性痴呆(AD)的发病机理和治疗法则，并期望建立一种新的AD大鼠模型，通过观察补肾化痰法对该模型大鼠学习记忆水平、脑组织病理形态、胆碱能系统和泛素-蛋白酶体通路相关指标的影响，探讨补肾化痰法对该AD模型的干预作用和作用机理，为中医药防治AD提供实验依据。