Stirring at room temperature for h with fold thionyl chloride of the substrate、0mL acetone and 0.～0. mL trimethyl orthoformate per gram substrate respectively,the yield reached 90.%(adenosine) and 89.%(inosine).
Stirring at room temperature for h with fold thionyl chloride of the substrate、0mL acetone and 0.～0. mL trimethyl orthoformate per gram substrate respectively,the yield reached 90.%(adenosine) and 89.%(inosine).
最佳的工艺条件为:常温反应h,氯化亚砜用量为底物的 倍,丙酮和原甲酸三甲酯的用量分别为每克底物0mL和0.～0. mL,收率90.%(腺苷)和89.%(肌苷)。