But during the transition from metaphase to anaphase, APC is activated and it discomposes the securin. Then the separse what is a protease has activity and it discompose cohesin. So the sister chromatids separate.
But during the transition from metaphase to anaphase, APC is activated and it discomposes the securin. Then the separse what is a protease has activity and it discompose cohesin. So the sister chromatids separate.
通常情况下分离酶受到保全素(securin/PTTG)的抑制而没有活性,当细胞从有丝分裂中期向后期转变时,APC(anaphase-promoting complex, 后期促进复合体)被激活并裂解保全素,具有蛋白酶活性的分离酶裂解粘合姐妹染色单体的粘合素(cohesin),姐妹染色单体分离。