As a result,the pharmacokinetics of matrine in rabbit body coincides with two-compartment open model. For 10-30mg/kg dosage groups,the t_(1/2)β,Vc and CLS are similar basically. A direct proportion increase in AUC as dose is increased.
As a result,the pharmacokinetics of matrine in rabbit body coincides with two-compartment open model. For 10-30mg/kg dosage groups,the t_(1/2)β,Vc and CLS are similar basically. A direct proportion increase in AUC as dose is increased.
结果表明,苦参碱在家兔体内药代动力学符合二室开放模型,10～30mg/kg时t_1/2β,V_c,CLS基本相似,AUC与剂量成比例增加,呈线性消除。