The folate receptor(FR) is an over-expressed tumor-associated antigen that binds folate and folate-drug conjugates with very high affinity and shuttles these bound molecules inside cells via an endocytic mechanism.
The folate receptor(FR) is an over-expressed tumor-associated antigen that binds folate and folate-drug conjugates with very high affinity and shuttles these bound molecules inside cells via an endocytic mechanism.
叶酸受体在肿瘤细胞中都有过度表达,通过其介导细胞内化能够将叶酸摄取入细胞浆内,因此利用叶酸受体与叶酸及其类似物偶联的分子显像剂特异性结合,可以达到肿瘤组织靶向分布和显像目的,在肿瘤诊断和治疗方面很有前景。