Its Tmax is about min and t/β is about 0min in rat.The uretic effection was observed after 80min when the concentration of Matrine in rat plasma had significant decreased.
Its Tmax is about min and t/β is about 0min in rat.The uretic effection was observed after 80min when the concentration of Matrine in rat plasma had significant decreased.
最大效应出现在灌服的 0min后 ,且维持时间可达灌服后的 80min ,大鼠口服后血浆药物达峰时间Tmax平均为 min ,t/ β平均为0 min。 结论 :苦参碱对家兔有显著的利尿作用 ,其效应的维持相对滞后于药物在血浆中的衰减。